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Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition

Regulated conformational changes of proteins are critical for cellular signal transduction. The spindle checkpoint protein Mad2 is an unusual protein with two native folds: the latent open conformer (O-Mad2) and the activated closed conformer (C-Mad2). During mitosis, cytosolic O-Mad2 binds to the M...

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Autores principales: Kim, Soonjoung, Sun, Hongbin, Ball, Haydn L., Wassmann, Katja, Luo, Xuelian, Yu, Hongtao
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993392/
https://ncbi.nlm.nih.gov/pubmed/21041666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009000107
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