Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)

The enzyme MurA has been an established antibiotic target since the discovery of fosfomycin, which specifically inhibits MurA by covalent modification of the active site residue Cys-115. Early biochemical studies established that Cys-115 also covalently reacts with substrate phosphoenolpyruvate (PEP...

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Bibliographische Detailangaben
Hauptverfasser: Zhu, Jin-Yi, Yang, Yan, Han, Huijong, Betzi, Stephane, Olesen, Sanne H., Marsilio, Frank, Schönbrunn, Ernst
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339971/
https://ncbi.nlm.nih.gov/pubmed/22378791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.342725
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