The Fungal Product Terreic Acid is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA)

Terreic acid is a metabolite with antibiotic properties produced by the fungus Aspergillus terreus. We found that terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme MurA from E. cloacae and E. coli in-vitro. The crystal structure of the MurA dead-end complex with ter...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Han, Huijong, Yang, Yan, Olesen, Sanne H., Becker, Andreas, Betzi, Stephane, Schönbrunn, Ernst
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884014/
https://ncbi.nlm.nih.gov/pubmed/20392080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100365b
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