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Contribution of Residues in Second Transmembrane Domain of ASIC1a Protein to Ion Selectivity
Acid-sensing ion channels (ASICs) are proton-gated cation-selective channels expressed in the peripheral and central nervous systems. The ion permeation pathway of ASIC1a is defined by residues 426–450 in the second transmembrane (TM2) segment. The gate, formed by the intersection of the TM2 segment...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3339937/ https://ncbi.nlm.nih.gov/pubmed/22371494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.329284 |
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