An Extra Amino Acid Residue in Transmembrane Domain 10 of the γ-Aminobutyric Acid (GABA) Transporter GAT-1 Is Required for Efficient Ion-coupled Transport

The GABA transporter GAT-1 mediates electrogenic transport of its substrate together with sodium and chloride. It is a member of the neurotransmitter:sodium:symporters, which are crucial for synaptic transmission. Compared with all other neurotransmitter:sodium:symporters, GAT-1 and other members of...

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Vydáno v:J Biol Chem
Hlavní autoři: Dayan, Oshrat, Nagarajan, Anu, Shah, Raven, Ben-Yona, Assaf, Forrest, Lucy R., Kanner, Baruch I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392685/
https://ncbi.nlm.nih.gov/pubmed/28213519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775189
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