Conformationally Sensitive Proximity of Extracellular Loops 2 and 4 of the γ-Aminobutyric Acid (GABA) Transporter GAT-1 Inferred from Paired Cysteine Mutagenesis

The sodium- and chloride-coupled GABA transporter GAT-1 is a member of the neurotransmitter:sodium:symporters, which are crucial for synaptic transmission. Structural work on the bacterial homologue LeuT suggests that extracellular loop 4 closes the extracellular solvent pathway when the transporter...

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Vydáno v:J Biol Chem
Hlavní autoři: Hilwi, Maram, Dayan, Oshrat, Kanner, Baruch I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256357/
https://ncbi.nlm.nih.gov/pubmed/25339171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593061
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