Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs topoisomerase I cleavage complexes (Top1cc) by hydrolyzing their 3′-phosphotyrosyl DNA bonds and repairs bleomycin-induced DNA damage by hydrolyzing 3′-phosphoglycolates. Yeast Tdp1 has also been implicated in the repair of topoisomerase II-DNA cleavage...

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Detaylı Bibliyografya
Asıl Yazarlar: Murai, Junko, Huang, Shar-yin N., Das, Benu Brata, Dexheimer, Thomas S., Takeda, Shunichi, Pommier, Yves
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2012
Konular:
Cell Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339927/
https://ncbi.nlm.nih.gov/pubmed/22375014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333963
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