Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants

BACKGROUND: Acid sphingomyelinase (ASM) hydrolyses sphingomyelin and generates the lipid messenger ceramide, which mediates a variety of stress-related cellular processes. The pathological effects of dysregulated ASM activity are evident in several human diseases and indicate an important functional...

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Main Authors: Rhein, Cosima, Tripal, Philipp, Seebahn, Angela, Konrad, Alice, Kramer, Marcel, Nagel, Christine, Kemper, Jonas, Bode, Jens, Mühle, Christiane, Gulbins, Erich, Reichel, Martin, Becker, Cord-Michael, Kornhuber, Johannes
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338701/
https://ncbi.nlm.nih.gov/pubmed/22558155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035467
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