Characterization of Acid Sphingomyelinase Activity in Human Cerebrospinal Fluid

BACKGROUND: As a key enzyme in sphingolipid metabolism, acid sphingomyelinase (ASM) is involved in the regulation of cell fate and signaling via hydrolysis of sphingomyelin to form ceramide. While increased activity of the lysosomal form has been associated with various pathological conditions, ther...

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Main Authors: Mühle, Christiane, Huttner, Hagen B., Walter, Silke, Reichel, Martin, Canneva, Fabio, Lewczuk, Piotr, Gulbins, Erich, Kornhuber, Johannes
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642176/
https://ncbi.nlm.nih.gov/pubmed/23658784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062912
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