Dose-Dependent Effects of Sirolimus on mTOR Signaling and Polycystic Kidney Disease

Inhibition of the mammalian target of rapamycin (mTOR) shows beneficial effects in animal models of polycystic kidney disease (PKD); however, two clinical trials in patients with autosomal dominant PKD failed to demonstrate a short-term benefit in either the early or progressive stages of disease. T...

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Main Authors: Novalic, Zlata, van der Wal, Annemieke M., Leonhard, Wouter N., Koehl, Gudrun, Breuning, Martijn H., Geissler, Edward K., de Heer, Emile, Peters, Dorien J.M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2012
Assuntos:
Basic Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338286/
https://ncbi.nlm.nih.gov/pubmed/22343118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011040340
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