Quantification of Cre-mediated recombination by a novel strategy reveals a stable extra-chromosomal deletion-circle in mice

BACKGROUND: Inducible conditional knockout animals are widely used to get insight in the function of genes and the pathogenesis of human diseases. These models frequently rely on Cre-mediated recombination of sequences flanked by Lox-P sites. To understand the consequences of gene disruption, it is...

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Bibliografiske detaljer
Main Authors: Leonhard, Wouter N, Roelfsema, Jeroen H, Lantinga-van Leeuwen, Irma S, Breuning, Martijn H, Peters, Dorien JM
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2008
Fag:
Methodology Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2277394/
https://ncbi.nlm.nih.gov/pubmed/18298805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-8-18
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