BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway

By diversifying antibody biological effector functions, class switch DNA recombination has a central role in the maturation of the antibody response. Here we show that BCR-signalling synergizes with Toll-like receptor (TLR) signalling to induce class switch DNA recombination. BCR-signalling activate...

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Hauptverfasser: Pone, Egest J., Zhang, Jinsong, Mai, Thach, White, Clayton A., Li, Guideng, Sakakura, John K., Patel, Pina J., Al-Qahtani, Ahmed, Zan, Hong, Xu, Zhenming, Casali, Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337981/
https://ncbi.nlm.nih.gov/pubmed/22473011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1769
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