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Specific inhibition of human DNA ligase adenylation by a distamycin derivative possessing antitumor activity.

The antiviral distamycin A and its phenyl mustard derivative FCE24517 possessing antitumor activity were tested for their ability to inhibit macromolecular synthesis in three human and one murine cell line. While distamycin A was poorly active in these systems, FCE24517 inhibited DNA synthesis effic...

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Detalhes bibliográficos
Main Authors: Montecucco, A, Fontana, M, Focher, F, Lestingi, M, Spadari, S, Ciarrocchi, G
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC333782/
https://ncbi.nlm.nih.gov/pubmed/1708493
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