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Structural alterations of pathologically or physiologically modified DNA.
We have studied the alterations of DNA conformation in in vitro depurinated or methylated topological isomers of the plasmid pAT 153. Depurination by heat/acid treatment or alkylation by methyl methanesulfonate (pathological modifications) result in DNA unwinding detected as a reduction in the degre...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
1984
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC318634/ https://ncbi.nlm.nih.gov/pubmed/6366741 |
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