Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: Implications for preconditioning

BACKROUND: Reactive oxygen species (ROS) mediate the effects of anesthetic precondition to protect against ischemia and reperfusion injury, but the mechanisms of ROS generation remain unclear. In this study, we investigated if mitochondria-targeted antioxidant (mitotempol) abolishes the cardioprotec...

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Main Authors: Hirata, Naoyuki, Shim, Yon Hee, Pravdic, Danijel, Lohr, Nicole L., Pratt, Philip F., Weihrauch, Dorothee, Kersten, Judy R., Warltier, David C, Bosnjak, Zeljko J., Bienengraeber, Martin
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337729/
https://ncbi.nlm.nih.gov/pubmed/21862887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e31822a2316
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