Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: Implications for preconditioning

BACKROUND: Reactive oxygen species (ROS) mediate the effects of anesthetic precondition to protect against ischemia and reperfusion injury, but the mechanisms of ROS generation remain unclear. In this study, we investigated if mitochondria-targeted antioxidant (mitotempol) abolishes the cardioprotec...

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Autores principales: Hirata, Naoyuki, Shim, Yon Hee, Pravdic, Danijel, Lohr, Nicole L., Pratt, Philip F., Weihrauch, Dorothee, Kersten, Judy R., Warltier, David C, Bosnjak, Zeljko J., Bienengraeber, Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337729/
https://ncbi.nlm.nih.gov/pubmed/21862887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e31822a2316
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