Frequency of EGFR and KRAS Mutations in Lung Adenocarcinomas in African-Americans

INTRODUCTION: The detection of mutations in the epidermal growth factor receptor (EGFR) gene, which predict sensitivity to treatment with EGFR tyrosine kinase inhibitors (TKIs), represents a major advance in the treatment of lung adenocarcinoma. KRAS mutations confer resistance to EGFR -TKIs. The pr...

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Main Authors: Reinersman, J. Matthew, Johnson, Melissa L., Riely, Gregory J., Chitale, Dhananjay A., Nicastri, Anthony D., Soff, Gerald A., Schwartz, Ann G., Sima, Camelia S., Ayalew, Getinet, Lau, Christopher, Zakowski, Maureen F., Rusch, Valerie W., Ladanyi, Marc, Kris, Mark G.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337520/
https://ncbi.nlm.nih.gov/pubmed/21107288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e3181fb4fe2
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