EGFR Mutations in Lung Adenocarcinomas: Clinical Testing Experience and Relationship to EGFR Gene Copy Number and Immunohistochemical Expression

Lung adenocarcinomas responsive to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors possess EGFR mutations and often increased EGFR copy number. We prospectively studied 334 clinical cases using polymerase chain reaction-based assays to detect deletions within exon 19 and the L858R...

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Detalhes bibliográficos
Main Authors: Li, Allan R., Chitale, Dhananjay, Riely, Gregory J., Pao, William, Miller, Vincent A., Zakowski, Maureen F., Rusch, Valerie, Kris, Mark G., Ladanyi, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2329789/
https://ncbi.nlm.nih.gov/pubmed/18403609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2008.070178
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