EGFR Mutations in Lung Adenocarcinomas: Clinical Testing Experience and Relationship to EGFR Gene Copy Number and Immunohistochemical Expression

Lung adenocarcinomas responsive to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors possess EGFR mutations and often increased EGFR copy number. We prospectively studied 334 clinical cases using polymerase chain reaction-based assays to detect deletions within exon 19 and the L858R...

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Bibliographische Detailangaben
Hauptverfasser: Li, Allan R., Chitale, Dhananjay, Riely, Gregory J., Pao, William, Miller, Vincent A., Zakowski, Maureen F., Rusch, Valerie, Kris, Mark G., Ladanyi, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2008
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Regular Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2329789/
https://ncbi.nlm.nih.gov/pubmed/18403609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2008.070178
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