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Tumor suppressor function of RUNX3 in breast cancer
Emerging evidence indicates that RUNX3 is a tumor suppressor in breast cancer. RUNX3 is frequently inactivated in human breast cancer cell lines and cancer samples by hemizygous deletion of the Runx3 gene, hypermethylation of the Runx3 promoter, or cytoplasmic sequestration of RUNX3 protein. Inactiv...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3337355/ https://ncbi.nlm.nih.gov/pubmed/22275124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.24074 |
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