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Hypoxia-Inducible Factor Activation in Myeloid Cells Contributes to the Development of Liver Fibrosis in Cholestatic Mice

Macrophages play an integral role in the development of liver fibrosis by releasing mediators, such as platelet-derived growth factor-B (PDGF-B) and transforming growth factor-β1, which stimulate hepatic stellate cell proliferation, chemotaxis, and collagen production. However, the mechanism by whic...

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Autors principals: Copple, Bryan L., Kaska, Sophia, Wentling, Callie
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336817/
https://ncbi.nlm.nih.gov/pubmed/22271822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.189340
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