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Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis

Accumulation of hydrophobic bile acids in the liver contributes to cholestatic liver injury. Inflammation induced by excessive bile acids is believed to play a crucial role, however, the mechanisms of bile acids triggered inflammatory response remain unclear. Recent studies have highlighted the effe...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Gong, Zizhen, Zhou, Jiefei, Zhao, Shengnan, Tian, Chunyan, Wang, Panliang, Xu, Congfeng, Chen, Yingwei, Cai, Wei, Wu, Jin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356637/
https://ncbi.nlm.nih.gov/pubmed/27924062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13796
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