Granzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4(+) T cells

Some human memory CD4(+) T cells have cytotoxic functions best understood in the context of viral infections; however, their possible role in pathologic processes is understudied. The novel discovery that mitogenic CD28 antibodies induced proliferation and expansion of Tregs offered therapeutic prom...

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Main Authors: Medina, Miguel A., Couturier, Jacob, Feske, Marsha L., Mahne, Ashley E., Turner, Mary, Yu, Xiaoyong, Kozinetz, Claudia A., Orozco, Aaron F., Hutchison, Alexander T., Savidge, Tor C., Rodgers, John R., Lewis, Dorothy E.
Format: Artigo
Jezik:Inglês
Izdano: Society for Leukocyte Biology 2012
Teme:
Inflammation, Extracellular Mediators, & Effector Molecules
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336770/
https://ncbi.nlm.nih.gov/pubmed/22416257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0511264
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