HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: implications for bystander cell and tissue pathologies

Granzyme B (GrzB) is expressed by activated T cells and mediates cellular apoptosis. GrzB also acts as an extracellular protease involved in tissue degradation. We hypothesized that GrzB production from activated memory CD4 T cells may be associated with HIV pathogenesis. We found that stimulated me...

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Hauptverfasser: Couturier, Jacob, Hutchison, Alexander T., Medina, Miguel A., Gingaras, Cosmina, Urvil, Petri, Yu, Xiaoying, Nguyen, Chi, Mahale, Parag, Lin, Lin, Kozinetz, Claudia A., Schmitz, Joern E., Kimata, Jason T., Savidge, Tor C., Lewis, Dorothy E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158656/
https://ncbi.nlm.nih.gov/pubmed/24999042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.06.008
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