Granzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4(+) T cells

Some human memory CD4(+) T cells have cytotoxic functions best understood in the context of viral infections; however, their possible role in pathologic processes is understudied. The novel discovery that mitogenic CD28 antibodies induced proliferation and expansion of Tregs offered therapeutic prom...

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Autors principals: Medina, Miguel A., Couturier, Jacob, Feske, Marsha L., Mahne, Ashley E., Turner, Mary, Yu, Xiaoyong, Kozinetz, Claudia A., Orozco, Aaron F., Hutchison, Alexander T., Savidge, Tor C., Rodgers, John R., Lewis, Dorothy E.
Format: Artigo
Idioma:Inglês
Publicat: Society for Leukocyte Biology 2012
Matèries:
Inflammation, Extracellular Mediators, & Effector Molecules
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336770/
https://ncbi.nlm.nih.gov/pubmed/22416257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0511264
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