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Regulation of nuclear TDP-43 by NR2A-containing NMDA receptors and PTEN

The dysfunction of TAR DNA-binding protein-43 (TDP-43) is implicated in neurodegenerative diseases. However, the function of TDP-43 is not fully elucidated. Here we show that the protein level of endogenous TDP-43 in the nucleus is increased in mouse cortical neurons in the early stages, but return...

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Hlavní autoři: Zheng, Mei, Liao, Mingxia, Cui, Tianyuan, Tian, Honglin, Fan, Dong-Sheng, Wan, Qi
Médium: Artigo
Jazyk:Inglês
Vydáno: Company of Biologists 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336381/
https://ncbi.nlm.nih.gov/pubmed/22526419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.095729
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