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Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons

Loss of the nuclear RNA binding protein TAR DNA binding protein-43 (TDP-43) into cytoplasmic aggregates is the strongest correlate to neurodegeneration in amyotrophic lateral sclerosis and frontotemporal degeneration. The molecular changes associated with the loss of nuclear TDP-43 in human tissues...

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Pubblicato in:Cell Rep
Autori principali: Liu, Elaine Y., Russ, Jenny, Cali, Christopher P., Phan, Jessica M., Amlie-Wolf, Alexandre, Lee, Edward B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6508629/
https://ncbi.nlm.nih.gov/pubmed/31042469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.04.003
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