Epigenetic silencing of HNF1A associates with changes in the composition of the human plasma N-glycome

Protein glycosylation is a ubiquitous modification that affects the structure and function of proteins. Our recent genome wide association study identified transcription factor HNF1A as an important regulator of plasma protein glycosylation. To evaluate the potential impact of epigenetic regulation...

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Autors principals: Zoldoš, Vlatka, Horvat, Tomislav, Novokmet, Mislav, Cuenin, Cyrille, Mužinić, Ana, Pučić, Maja, Huffman, Jennifer E, Gornik, Olga, Polašek, Ozren, Campbell, Harry, Hayward, Caroline, Wright, Alan F, Rudan, Igor, Owen, Katharine, McCarthy, Mark I, Herceg, Zdenko, Lauc, Gordan
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2012
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335910/
https://ncbi.nlm.nih.gov/pubmed/22395466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.7.2.18918
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