Genomics Meets Glycomics—The First GWAS Study of Human N-Glycome Identifies HNF1α as a Master Regulator of Plasma Protein Fucosylation

Over half of all proteins are glycosylated, and alterations in glycosylation have been observed in numerous physiological and pathological processes. Attached glycans significantly affect protein function; but, contrary to polypeptides, they are not directly encoded by genes, and the complex process...

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Main Authors: Lauc, Gordan, Essafi, Abdelkader, Huffman, Jennifer E., Hayward, Caroline, Knežević, Ana, Kattla, Jayesh J., Polašek, Ozren, Gornik, Olga, Vitart, Veronique, Abrahams, Jodie L., Pučić, Maja, Novokmet, Mislav, Redžić, Irma, Campbell, Susan, Wild, Sarah H., Borovečki, Fran, Wang, Wei, Kolčić, Ivana, Zgaga, Lina, Gyllensten, Ulf, Wilson, James F., Wright, Alan F., Hastie, Nicholas D., Campbell, Harry, Rudd, Pauline M., Rudan, Igor
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009678/
https://ncbi.nlm.nih.gov/pubmed/21203500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001256
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