Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites.

Camptothecin (CPT), a plant alkaloid with antitumor activity, is a specific inhibitor of eukaryotic DNA topoisomerase I. We have previously isolated and characterized a CPT-resistant topoisomerase I isolated from a CPT-resistant human leukemia cell line, CPT-K5. cDNA clones of topoisomerase I were i...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Tamura, H, Kohchi, C, Yamada, R, Ikeda, T, Koiwai, O, Patterson, E, Keene, J D, Okada, K, Kjeldsen, E, Nishikawa, K
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 1991
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC333535/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1849260/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/19.1.69
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