Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

Mutations leading to expansion of a poly-glutamine track in Huntingtin (Htt) cause Huntington's disease (HD). Signs of endoplasmic reticulum (ER) stress have been recently reported in animal models of HD, associated with the activation of the unfolded protein response (UPR). Here we have invest...

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Bibliographic Details
Main Authors: Vidal, Rene L., Figueroa, Alicia, Court, Felipe A., Thielen, Peter, Molina, Claudia, Wirth, Craig, Caballero, Benjamin, Kiffin, Roberta, Segura-Aguilar, Juan, Cuervo, Ana Maria, Glimcher, Laurie H., Hetz, Claudio
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335312/
https://ncbi.nlm.nih.gov/pubmed/22337954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds040
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