Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

Mutations leading to expansion of a poly-glutamine track in Huntingtin (Htt) cause Huntington's disease (HD). Signs of endoplasmic reticulum (ER) stress have been recently reported in animal models of HD, associated with the activation of the unfolded protein response (UPR). Here we have invest...

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Main Authors: Vidal, Rene L., Figueroa, Alicia, Court, Felipe A., Thielen, Peter, Molina, Claudia, Wirth, Craig, Caballero, Benjamin, Kiffin, Roberta, Segura-Aguilar, Juan, Cuervo, Ana Maria, Glimcher, Laurie H., Hetz, Claudio
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335312/
https://ncbi.nlm.nih.gov/pubmed/22337954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds040
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