Designing photoswitchable peptides using the AsLOV2 domain

Photocontrol of functional peptides is a powerful tool for spatial and temporal control of cell signaling events. We show that the genetically encoded light-sensitive LOV2 domain of Avena Sativa phototropin 1 (AsLOV2) can be used to reversibly photomodulate the affinity of peptides for their binding...

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Bibliografiske detaljer
Main Authors: Lungu, Oana I., Hallett, Ryan A., Choi, Eun Jung, Aiken, Mary J., Hahn, Klaus M., Kuhlman, Brian
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334866/
https://ncbi.nlm.nih.gov/pubmed/22520757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.02.006
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