DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

BACKGROUND: Organic cation transporters (OCTs) determine not only physiological processes but are also involved in the cellular uptake of anticancer agents. Based on microarray analyses in hepatocellular carcinoma (HCC), SLC22A1/OCT1 mRNA seems to be downregulated, but systematic protein expression...

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Bibliographische Detailangaben
Hauptverfasser: Schaeffeler, Elke, Hellerbrand, Claus, Nies, Anne T, Winter, Stefan, Kruck, Stephan, Hofmann, Ute, van der Kuip, Heiko, Zanger, Ulrich M, Koepsell, Hermann, Schwab, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334547/
https://ncbi.nlm.nih.gov/pubmed/22196450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm298
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