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Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases

Targeted gene addition to mammalian genomes is central to biotechnology, basic research and gene therapy. For example, gene targeting to the ROSA26 locus by homologous recombination in embryonic stem cells is commonly used for mouse transgenesis to achieve ubiquitous and persistent transgene express...

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Détails bibliographiques
Auteurs principaux: Perez-Pinera, Pablo, Ousterout, David G., Brown, Matthew T., Gersbach, Charles A.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3333879/
https://ncbi.nlm.nih.gov/pubmed/22169954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1214
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