Identification of a small molecule yeast TORC1 inhibitor with a flow cytometry-based multiplex screen

TOR (target of rapamycin) is a serine/threonine kinase, evolutionarily conserved from yeast to human, which functions as a fundamental controller of cell growth. The moderate clinical benefit of rapamycin in mTOR-based therapy of many cancers favors the development of new TOR inhibitors. Here we rep...

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Hauptverfasser: Chen, Jun, Young, Susan M., Allen, Chris, Seeber, Andrew, Péli-Gulli, Marie-Pierre, Panchaud, Nicolas, Waller, Anna, Ursu, Oleg, Yao, Tuanli, Golden, Jennifer E., Strouse, J. Jacob, Carter, Mark B., Kang, Huining, Bologa, Cristian G., Foutz, Terry D., Edwards, Bruce S., Peterson, Blake R., Aubé, Jeffrey, Werner-Washburne, Margaret, Loewith, Robbie J., De Virgilio, Claudio, Sklar, Larry A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331904/
https://ncbi.nlm.nih.gov/pubmed/22260433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200452r
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