Structural insights into human KAP1 PHD finger–bromodomain and its role in gene silencing

The tandem PHD finger–bromodomain, found in many chromatin-associated proteins, has an important role in gene silencing by the human co-repressor KRAB-associated protein 1 (KAP1). Here we report the three-dimensional solution structure of the tandem PHD finger–bromodomain of KAP1. The structure reve...

Full description

Saved in:
Bibliographic Details
Main Authors: Zeng, Lei, Yap, Kyoko L, Ivanov, Alexey V, Wang, Xueqi, Mujtaba, Shiraz, Plotnikova, Olga, Rauscher, Frank J, Zhou, Ming-Ming
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331790/
https://ncbi.nlm.nih.gov/pubmed/18488044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1416
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items