Prevention of Type 1 Diabetes in the Rat With an Allele-Specific Anti–T-Cell Receptor Antibody: Vβ13 as a Therapeutic Target and Biomarker

In earlier studies of the Iddm14 diabetes susceptibility locus in the rat, we identified an allele of the T-cell receptor (TCR) β-chain, Tcrb-V13S1A1, as a candidate gene. To establish its importance, we treated susceptible rats with a depleting anti-rat Vβ13 monoclonal antibody and then exposed the...

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Autors principals: Liu, Zhijun, Cort, Laura, Eberwine, Ryan, Herrmann, Thomas, Leif, Jean H., Greiner, Dale L., Yahalom, Barak, Blankenhorn, Elizabeth P., Mordes, John P.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2012
Matèries:
Immunology and Transplantation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331757/
https://ncbi.nlm.nih.gov/pubmed/22368175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0867
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