Virus-Induced Autoimmune Diabetes in the LEW.1WR1 Rat Requires Iddm14 and a Genetic Locus Proximal to the Major Histocompatibility Complex

OBJECTIVE: To identify genes that confer susceptibility to autoimmune diabetes following viral infection in the LEW.1WR1 rat. RESEARCH DESIGN AND METHODS: About 2% of LEW.1WR1 rats develop spontaneous autoimmune diabetes. Immunological perturbants including viral infection increase both the frequenc...

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Detalhes bibliográficos
Main Authors: Blankenhorn, Elizabeth P., Cort, Laura, Greiner, Dale L., Guberski, Dennis L., Mordes, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780864/
https://ncbi.nlm.nih.gov/pubmed/19720792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0387
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