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Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus

Iddm14 (formerly Iddm4) is a non-MHC-linked genetic locus associated with autoimmune diabetes. Its effects have been well-documented in BB-derived rats in which diabetes is either induced by immunologic perturbation or occurs spontaneously. The role of Iddm14 in non-BB rat strains is unknown. Our go...

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Detalhes bibliográficos
Main Authors: Mordes, John P., Cort, Laura, Norowski, Elaine, Leif, Jean, Fuller, Jessica M., Lernmark, Åke, Greiner, Dale L., Blankenhorn, Elizabeth P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962255/
https://ncbi.nlm.nih.gov/pubmed/19205800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00335-009-9172-y
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