Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction

[Image: see text] The human immunodeficiency virus type 1 (HIV-1) capsid protein (CA) plays a critical role in the viral life cycle. The C-terminal domain (CTD) of CA binds to human lysyl-tRNA synthetase (hLysRS), and this interaction facilitates packaging of host cell tRNA(Lys,3), which serves as t...

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Autori principali: Dewan, Varun, Liu, Tao, Chen, Kuan-Ming, Qian, Ziqing, Xiao, Yong, Kleiman, Lawrence, Mahasenan, Kiran V., Li, Chenglong, Matsuo, Hiroshi, Pei, Dehua, Musier-Forsyth, Karin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2012
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330833/
https://ncbi.nlm.nih.gov/pubmed/22276994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200450w
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