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Differential determinants for coupling of distinct G proteins with the class B secretin receptor

The secretin receptor is a prototypic class B G protein-coupled receptor that is activated by binding of its natural peptide ligand. The signaling effects of this receptor are mediated by coupling with Gs, which activates cAMP production, and Gq, which activates intracellular calcium mobilization. W...

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Bibliografiske detaljer
Main Authors: Garcia, Gene L., Dong, Maoqing, Miller, Laurence J.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330731/
https://ncbi.nlm.nih.gov/pubmed/22277758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00273.2011
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