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Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor

The secretin receptor is a prototypic member of family B G protein-coupled receptors that binds and responds to a linear 27-residue peptide natural ligand. The carboxyl-terminal region of this peptide assumes a helical conformation that occupies the peptide-binding cleft within the structurally comp...

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Autors principals: Miller, Laurence J, Dong, Maoqing, Harikumar, Kaleeckal G
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415634/
https://ncbi.nlm.nih.gov/pubmed/21542831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01463.x
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