Functional Importance of a Structurally Distinct Homodimeric Complex of the Family B G Protein-Coupled Secretin Receptor

Oligomerization of G protein-coupled receptors has been described, but its structural basis and functional importance have been inconsistent. Here, we demonstrate that the agonist occupied wild-type secretin receptor is predominantly in a guanine nucleotide-sensitive high-affinity state and exhibits...

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Main Authors: Gao, Fan, Harikumar, Kaleeckal G., Dong, Maoqing, Lam, Polo C.-H., Sexton, Patrick M., Christopoulos, Arthur, Bordner, Andrew, Abagyan, Ruben, Miller, Laurence J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713122/
https://ncbi.nlm.nih.gov/pubmed/19429716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.055756
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