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Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factor

Clostridium difficile, a causative agent of antibiotic-associated diarrhea and its potentially lethal form, pseudomembranous colitis, produces two large protein toxins that are responsible for the cellular damage associated with the disease. The level of toxin production appears to be critical for d...

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Bibliografiske detaljer
Main Authors: Mani, Nagraj, Dupuy, Bruno
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC33301/
https://ncbi.nlm.nih.gov/pubmed/11320220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101126598
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