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Opposing Synaptic Regulation of Amyloid-β Metabolism by NMDA Receptors In Vivo

The concentration of amyloid-β (Aβ) within the brain extracellular space is one determinant of whether the peptide will aggregate into toxic species that are important in Alzheimer's disease (AD) pathogenesis. Some types of synaptic activity can regulate Aβ levels. Here we demonstrate two disti...

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Autors principals: Verges, Deborah K., Restivo, Jessica L., Goebel, Whitney D., Holtzman, David M., Cirrito, John R.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329800/
https://ncbi.nlm.nih.gov/pubmed/21813692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0607-11.2011
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