Dynamic Reprogramming of the Kinome In Response to Targeted MEK Inhibition In Triple Negative Breast Cancer

Kinase inhibitors have limited success in cancer treatment because tumors circumvent their action. Using a quantitative proteomics approach, we assessed kinome activity in response to MEK inhibition in triple negative breast cancer (TNBC) cells and genetically engineered mice (GEMMs). MEK inhibition...

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Main Authors: Duncan, James S., Whittle, Martin C., Nakamura, Kazuhiro, Abell, Amy N., Midland, Alicia A., Zawistowski, Jon S., Johnson, Nancy L., Granger, Deborah A., Jordan, Nicole Vincent, Darr, David B., Usary, Jerry, Kuan, Pei-Fen, Smalley, David M., Major, Ben, He, Xiaping, Hoadley, Katherine A., Zhou, Bing, Sharpless, Norman E., Perou, Charles M., Kim, William Y., Gomez, Shawn M., Chen, Xin, Jin, Jian, Frye, Stephen V., Earp, H. Shelton, Graves, Lee M., Johnson, Gary L.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328787/
https://ncbi.nlm.nih.gov/pubmed/22500798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.02.053
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