Dynamic Reprogramming of the Kinome In Response to Targeted MEK Inhibition In Triple Negative Breast Cancer

Kinase inhibitors have limited success in cancer treatment because tumors circumvent their action. Using a quantitative proteomics approach, we assessed kinome activity in response to MEK inhibition in triple negative breast cancer (TNBC) cells and genetically engineered mice (GEMMs). MEK inhibition...

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Κύριοι συγγραφείς: Duncan, James S., Whittle, Martin C., Nakamura, Kazuhiro, Abell, Amy N., Midland, Alicia A., Zawistowski, Jon S., Johnson, Nancy L., Granger, Deborah A., Jordan, Nicole Vincent, Darr, David B., Usary, Jerry, Kuan, Pei-Fen, Smalley, David M., Major, Ben, He, Xiaping, Hoadley, Katherine A., Zhou, Bing, Sharpless, Norman E., Perou, Charles M., Kim, William Y., Gomez, Shawn M., Chen, Xin, Jin, Jian, Frye, Stephen V., Earp, H. Shelton, Graves, Lee M., Johnson, Gary L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2012
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328787/
https://ncbi.nlm.nih.gov/pubmed/22500798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.02.053
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