Dynamic Reprogramming of the Kinome In Response to Targeted MEK Inhibition In Triple Negative Breast Cancer

Kinase inhibitors have limited success in cancer treatment because tumors circumvent their action. Using a quantitative proteomics approach, we assessed kinome activity in response to MEK inhibition in triple negative breast cancer (TNBC) cells and genetically engineered mice (GEMMs). MEK inhibition...

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Autors principals: Duncan, James S., Whittle, Martin C., Nakamura, Kazuhiro, Abell, Amy N., Midland, Alicia A., Zawistowski, Jon S., Johnson, Nancy L., Granger, Deborah A., Jordan, Nicole Vincent, Darr, David B., Usary, Jerry, Kuan, Pei-Fen, Smalley, David M., Major, Ben, He, Xiaping, Hoadley, Katherine A., Zhou, Bing, Sharpless, Norman E., Perou, Charles M., Kim, William Y., Gomez, Shawn M., Chen, Xin, Jin, Jian, Frye, Stephen V., Earp, H. Shelton, Graves, Lee M., Johnson, Gary L.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328787/
https://ncbi.nlm.nih.gov/pubmed/22500798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.02.053
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