B cell–intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice

Wiskott Aldrich syndrome (WAS) is caused by mutations in the WAS gene that encodes for a protein (WASp) involved in cytoskeleton organization in hematopoietic cells. Several distinctive abnormalities of T, B, and natural killer lymphocytes; dendritic cells; and phagocytes have been found in WASp-def...

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Auteurs principaux: Recher, Mike, Burns, Siobhan O., de la Fuente, Miguel A., Volpi, Stefano, Dahlberg, Carin, Walter, Jolan E., Moffitt, Kristin, Mathew, Divij, Honke, Nadine, Lang, Philipp A., Patrizi, Laura, Falet, Hervé, Keszei, Marton, Mizui, Masayuki, Csizmadia, Eva, Candotti, Fabio, Nadeau, Kari, Bouma, Gerben, Delmonte, Ottavia M., Frugoni, Francesco, Fomin, Angela B. Ferraz, Buchbinder, David, Lundequist, Emma Maria, Massaad, Michel J., Tsokos, George C., Hartwig, John, Manis, John, Terhorst, Cox, Geha, Raif S., Snapper, Scott, Lang, Karl S., Malley, Richard, Westerberg, Lisa, Thrasher, Adrian J., Notarangelo, Luigi D.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2012
Sujets:
Immunobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327460/
https://ncbi.nlm.nih.gov/pubmed/22302739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-379412
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