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Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis
During apoptosis, hundreds of proteins are cleaved by caspases, most of them by the executioner caspase-3. However, caspase-7, which shares the same substrate primary sequence preference as caspase-3, is better at cleaving poly(ADP ribose) polymerase 1 (PARP) and Hsp90 cochaperone p23, despite a low...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326497/ https://ncbi.nlm.nih.gov/pubmed/22451931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200934109 |
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