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Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins

To achieve swift cell demise during apoptosis, caspases cleave essential proteins for cell survival and removal. In addition to the binding of preferred amino acid sequences to its substrate-binding pocket, caspase-7 also uses exosites to select specific substrates. 4 lysine residues (K(38)KKK) loca...

詳細記述

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Desroches, Alexandre, Denault, Jean-Bernard
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815152/
https://ncbi.nlm.nih.gov/pubmed/31586028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909283116
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